With medical cannabis now legal in several states, clinicians need the most current and accurate knowledge available to prescribe marijuana products. Even clinicians who are not prescribing these drugs need to be informed so they can treat patients who are using marijuana recreationally and address their patients’ expectations of cannabis, which may not always be based on science. This seminar will overview the pharmacology and therapeutics of cannabis products as well as their potential impact on the patient, such as drug testing results, employment, and driving or operating machinery. The lecture will also review legal limitations of state cannabis laws.